The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 03, 2019

Filed:

Jun. 06, 2014
Applicants:

Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);

Sanofi Biotechnology, Paris, FR;

Inventors:

William J. Sasiela, Tarrytown, NY (US);

Viktoria Gusarova, Tarrytown, NY (US);

Anusch Peyman, Frankfurt am Main, DE;

Hans Ludwig Schäfer, Frankfurt am Main, DE;

Uwe Schwahn, Frankfurt am Main, DE;

Assignees:

SANOFI BIOTECHNOLOGY, Pari, FR;

REGENERON PHARMACEUTICALS, INC., Tarrytown, NY (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61P 9/10 (2006.01); C07K 16/40 (2006.01); A61K 31/4015 (2006.01); C07K 14/47 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/40 (2013.01); A61K 31/4015 (2013.01); A61K 39/3955 (2013.01); A61K 2039/505 (2013.01); C07K 14/4703 (2013.01); C07K 2317/21 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); Y02A 50/407 (2018.01);
Abstract

The present invention provides methods and compositions for inhibiting atherosclerotic plaque formation in a subject. In certain embodiments, the methods of the present invention comprise selecting a subject who has, or is at risk of developing, atherosclerosis, and administering to the subject a pharmaceutical composition comprising a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. In certain embodiments, the PCSK9 inhibitor is an anti-PCSK9 antibody, or antigen binding protein.


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