The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 03, 2019
Filed:
Feb. 09, 2016
Applicant:
Immunogen, Inc., Waltham, MA (US);
Inventor:
Wayne C. Widdison, Belmont, MA (US);
Assignee:
IMMUNOGEN, INC., Waltham, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/64 (2017.01); C07K 16/18 (2006.01); C07D 207/416 (2006.01); C07K 5/062 (2006.01); C07K 16/28 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/18 (2013.01); C07D 207/416 (2013.01); C07K 5/06026 (2013.01); C07K 5/06052 (2013.01); C07K 16/2863 (2013.01); A61K 39/0011 (2013.01); A61K 2039/505 (2013.01); C07K 2317/21 (2013.01);
Abstract
The invention relates to novel cell-binding agent-cytotoxic agent conjugate having a peptide linkers and more specifically to conjugates of formula (I). The invention also provides novel cytotoxic agents of formula (II), linker compounds represented by formula (III), and drug-linker compounds represented by formula (IV). The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.