The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 03, 2019

Filed:

Oct. 01, 2014
Applicants:

Medimmune, Llc, Gaithersburg, MD (US);

Humabs Biomed SA, Bellinzona, CH;

Inventors:

Ebony Benjamin, Gaithersburg, MD (US);

Nicole Kallewaard-LeLay, Gaithersburg, MD (US);

Josephine Mary McAuliffe, Gailthersburg, MD (US);

Frances Palmer-Hill, Gaithersburg, MD (US);

Leslie Wachter, Gaithersburg, MD (US);

Andy Yuan, Gaithersburg, MD (US);

Qing Zhu, Gaithersburg, MD (US);

Davide Corti, Bellinzona, CH;

Antonio Lanzavecchia, Bellinzona, CH;

Barbara Guarino, Bellinzona, CH;

Anna DeMarco, Bellinzona, CH;

Assignees:

MEDIMMUNE, LLC, Gaithersburg, MD (US);

HUMABS BIOMED SA, Bellinzona, CH;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/13 (2006.01); A61K 39/42 (2006.01); A61K 45/06 (2006.01); C07K 16/10 (2006.01); C12P 21/00 (2006.01); G01N 33/569 (2006.01); G01N 33/577 (2006.01);
U.S. Cl.
CPC ...
C07K 16/1018 (2013.01); A61K 39/42 (2013.01); A61K 45/06 (2013.01); C12P 21/005 (2013.01); G01N 33/56983 (2013.01); G01N 33/577 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/54 (2013.01); C07K 2317/55 (2013.01); C07K 2317/565 (2013.01); C07K 2317/569 (2013.01); C07K 2317/622 (2013.01); C07K 2317/624 (2013.01); C07K 2317/626 (2013.01); C07K 2317/76 (2013.01); G01N 2333/11 (2013.01);
Abstract

The invention relates to antibodies and binding fragments thereof that are capable of binding to influenza A virus hemagglutinin and neutralizing at least one group 1 subtype and at least 1 group 2 subtype of influenza A virus. In one embodiment, an antibody or binding fragment according to the invention is capable of binding to and/or neutralizing one or more influenza A virus group 1 subtypes selected from H1, H2, H5, H6, H8, H9, H11, H12, H13, H16 and H17 and variants thereof and one or more influenza A virus group 2 subtype selected from H3, H4, H7, H1, 0, H14 and H15 and variants thereof.


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