The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 03, 2019
Filed:
Oct. 30, 2017
Baxalta Incorporated, Bannockburn, IL (US);
Baxalta Gmbh, Zug, CH;
Patrick Küry, Düsseldorf, DE;
Nevena Tzekova, Düsseldorf, DE;
Hans-Peter Hartung, Düsseldorf, DE;
Corinna Hermann, Vienna, AT;
Birgit Maria Reipert, Deutsch-Wagram, AT;
Hans-Peter Schwarz, Vienna, AT;
Hartmut Ehrlich, Vienna, AT;
Sebastian Bunk, Vienna, AT;
Other;
Abstract
The present invention is based on the discovery of polyclonal IgG's ability to promote Schwann cell maturation, differentiation, and myelin production. Methods for treating non-idiopathic, demyelinating peripheral neuropathies in mammals, where the neuropathy is not immune-mediated or infection-mediated, through the administration of polyclonal IgG are provided. Types of demyelinating peripheral neuropathies treatable with the present invention include peripheral nerve trauma and toxin-induced peripheral neuropathies. Alternatively, a composition of polyclonal IgGs can be applied directly to a peripheral nerve cell to induce maturation, differentiation into a myelinating state, and myelin expression or promote cell survival.