The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 03, 2019
Filed:
Jun. 07, 2017
Applicant:
Geron Corporation, Menlo Park, CA (US);
Inventors:
Krisztina Pongracz, Oakland, CA (US);
Mahesh Ramaseshan, Sunnyvale, CA (US);
Assignee:
Geron Corporation, Menlo Park, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 1/00 (2006.01); C07H 19/10 (2006.01); C07H 19/20 (2006.01); C07H 21/00 (2006.01);
U.S. Cl.
CPC ...
C07H 21/00 (2013.01); C07H 1/00 (2013.01); C07H 19/10 (2013.01); C07H 19/20 (2013.01);
Abstract
This invention relates to antisense oligonucleotides comprising at least one N3'→P5′ phosphorodiamidate linkage (NPN) in the backbone, useful for modulating gene expression involved in the pathogenesis of a disease. Compounds useful as building blocks of said antisense oligonucleotides and methods of preparing building block compounds including NPN linkages are provided.