The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 03, 2019

Filed:

Oct. 01, 2018
Applicant:

Zonula Incorporated, Montreal, CA;

Inventors:

Arkadii Vaisburg, Kirkland, CA;

Orest William Blaschuk, Mamaroneck, NY (US);

Assignee:

Zonula, Inc., Kirkland, Quebec, CA;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 211/58 (2006.01); A61P 35/00 (2006.01); A61K 9/70 (2006.01); A61K 45/06 (2006.01); A61P 19/02 (2006.01);
U.S. Cl.
CPC ...
C07D 211/58 (2013.01); A61K 9/7023 (2013.01); A61K 45/06 (2013.01); A61P 19/02 (2018.01); A61P 35/00 (2018.01);
Abstract

Compounds with activity as modulators of cell adhesion are disclosed. The compounds are derivatives of piperidin-4-amine. In some embodiments, a compound can be linked to a targeting agent, a pharmaceutically active substance and/or a support material. Methods for enhancing or inhibiting classical cadherin-mediated functions are also disclosed. The compounds can be used for the treatment or prevention of a variety of diseases including cancer. Compositions and devices, including skin patches comprising a compound are also disclosed. In addition, methods of synthesis of the compounds are provided.


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