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U.S. Cl.

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Abstract

The invention relates to compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 1-methyl-pseudouridine to improve one or more of the stability and/or clearance in tissues, receptor uptake and/or kinetics, cellular access by the compositions, engagement with translational machinery, mRNA half-life, translation efficiency, immune evasion, protein production capacity, secretion efficiency, accessibility to circulation, protein half-life and/or modulation of a cell's status, function, and/or activity.

Find Patent Forward Citations

de Fougerolles, Antonin. (2019). In vivo production of proteins (U.S. Patent No. 10493167). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10493167

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