The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 03, 2019
Filed:
Oct. 14, 2015
Applicant:
Texas Tech University System, Lubbock, TX (US);
Inventors:
Mingtao Zeng, El Paso, TX (US);
Junwei Li, El Paso, TX (US);
Assignee:
Texas Tech University System, Lubbock, TX (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/145 (2006.01); C12N 15/113 (2010.01); C12N 7/00 (2006.01); A61K 39/12 (2006.01); C12N 15/86 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/145 (2013.01); A61K 39/12 (2013.01); C12N 7/00 (2013.01); C12N 15/1131 (2013.01); C12N 15/86 (2013.01); A61K 2039/53 (2013.01); A61K 2039/545 (2013.01); A61K 2039/55 (2013.01); A61K 2039/575 (2013.01); C12N 2310/141 (2013.01); C12N 2330/51 (2013.01); C12N 2760/16123 (2013.01); C12N 2760/16134 (2013.01); C12N 2760/16151 (2013.01); C12N 2760/16161 (2013.01); C12N 2760/16171 (2013.01);
Abstract
The present invention includes a live attenuated virus and methods of making the same comprising an isolated virus comprising a viral genome that expresses one or more viral antigens; and one or more exogenous species-specific microRNAs inserted into the viral genome and expressed thereby, wherein the species-specific microRNAs are ubiquitously expressed in a viral target species cell but not in a viral propagation cell.