The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 03, 2019
Filed:
Sep. 29, 2016
Macau University of Science and Technology, Taipa, MO;
Yuen Kwan Law, Taipa, MO;
Kam Wai Wong, Taipa, MO;
An Gao Wu, Taipa, MO;
Liang Liu, Taipa, MO;
Zeng Wu, Taipa, MO;
MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY, Taipa, MO;
Abstract
A method for treating a subject suffering from a neurodegenerative disease includes administering at least one triterpenoid which can be obtained from. A method for treating a subject suffering from a neurodegenerative disease includes administering an effective amount of aextract which comprises the triterpenoid. The neurodegenerative disease is preferably but not exclusively Parkinson's disease or Huntington's disease. Methods for extracting the triterpenoid fromand a method for inducing autophagy in cells by contacting them with the triterpenoid are also provided. The triterpenoid allows an exceptional induction of autophagy, in particular a significant reduction of the protein level of mutant huntingtin, a significant reduction of the protein level of A53T α-synuclein, a significant inhibition of the oligomerization of α-synuclein and a significant inhibition of the inclusion formation of huntingtin via the AMPK-mTOR dependent autophagy inducing pathway.