The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 03, 2019

Filed:

Sep. 07, 2016
Applicant:

Neurocentria, Inc., Hayward, CA (US);

Inventors:

Guosong Liu, Oakland, CA (US);

Fei Mao, Fremont, CA (US);

Qifeng Sun, Beijing, CN;

Assignee:

Neurocentria, Inc., Hayward, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/191 (2006.01); A61K 45/06 (2006.01); A61K 33/06 (2006.01); A61K 31/14 (2006.01); A61K 33/00 (2006.01); A61K 33/26 (2006.01);
U.S. Cl.
CPC ...
A61K 31/191 (2013.01); A61K 31/14 (2013.01); A61K 33/00 (2013.01); A61K 33/06 (2013.01); A61K 33/26 (2013.01); A61K 45/06 (2013.01);
Abstract

Provided herein is a method of using threonate to alter cellular physiology, such as neuronal physiology. A method of the present disclosure may include providing to a medium comprising a cell, a threonate-containing compound, or a precursor thereof, to increase the concentration of threonate in the medium, where the increased concentration of threonate is sufficient to increase the concentration of magnesium in the cell. Also provided is a method that includes administering a threonate-containing compound, or a precursor thereof, to an individual, to increase synaptic density in the brain and/or to treat a neurological disorder, e.g., cognitive impairment. The threonate-containing compound of the present disclosure does not include magnesium threonate.


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