The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 03, 2019

Filed:

May. 08, 2017
Applicant:

Case Western Reserve University, Cleveland, OH (US);

Inventors:

Charlie Y. Wang, Cleveland, OH (US);

Mark A. Griswold, Shaker Heights, OH (US);

Xin Yu, Cleveland, OH (US);

Assignee:

Case Western Reserve University, Cleveland, OH (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61B 5/055 (2006.01); G01R 33/46 (2006.01); A61B 5/00 (2006.01); A61B 5/145 (2006.01); G01R 33/34 (2006.01); G01R 33/465 (2006.01); G01R 33/385 (2006.01); G01R 33/44 (2006.01);
U.S. Cl.
CPC ...
A61B 5/055 (2013.01); A61B 5/14546 (2013.01); A61B 5/4866 (2013.01); G01R 33/465 (2013.01); G01R 33/4625 (2013.01); A61B 2576/00 (2013.01); G01R 33/448 (2013.01);
Abstract

The present disclosure relates to a method for performing phosphorous-31 spectroscopic magnetic resonance fingerprinting (MRF). The method comprises performing a pulse sequence using a series of varied sequence blocks to a volume in a subject where the volume contains phosphate metabolites. A series of signal evolutions are acquired from the volume in the subject to form MRF data. The MRF data is then compared to simulated MRF signal to determine parameters associated with phosphate metabolites and the chemical exchange rates between these metabolites. These parameters and exchange rates can be used in diagnosing a metabolic disorder in a subject.


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