The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 26, 2019

Filed:

Oct. 30, 2015
Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Paul K. Hansma, Goleta, CA (US);

Kenneth S. Kosik, Santa Barbara, CA (US);

Luke S. K. Theogarajan, Carpinteria, CA (US);

Barney Drake, Truckee, CA (US);

Daniel C. Bridges, Santa Barbara, CA (US);

Connor J. Randall, Goleta, CA (US);

Kenneth R. Tovar, Portland, OR (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61N 1/00 (2006.01); G01N 33/483 (2006.01); C12M 3/00 (2006.01); C12M 1/42 (2006.01); C12M 1/36 (2006.01); G01N 15/10 (2006.01);
U.S. Cl.
CPC ...
G01N 33/4836 (2013.01); C12M 3/00 (2013.01); C12M 35/02 (2013.01); C12M 35/08 (2013.01); C12M 41/48 (2013.01); G01N 2015/1006 (2013.01);
Abstract

A Neural Circuit Probe (NCP) combines a multi-electrode array (MEA) with an automated local probe, wherein the probe is positioned to interact with one or more cells, such as neurons of a neural circuit, grown on or about one or more electrodes of the multi-electrode array. The probe may interact with the cells by electrically recording signals from the multi-electrode array that are assigned to a specific one of the cells. The probe may interact with the cells by locally delivering chemicals to the cells, which transiently and reversibly modulate the electrical behavior of the cells. The probe may interact with the cells by harvesting the cells using a pipette, so that the harvested cells can be sequenced.


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