The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 26, 2019

Filed:

Nov. 03, 2015
Applicant:

Merial, Inc., Duluth, GA (US);

Inventors:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/7088 (2006.01); C12N 15/63 (2006.01); C12N 1/21 (2006.01); C12P 19/34 (2006.01); C12P 21/06 (2006.01); A61P 31/04 (2006.01); C07K 14/00 (2006.01); C12N 15/73 (2006.01); C12N 15/85 (2006.01); C12P 21/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/73 (2013.01); C12N 15/635 (2013.01); C12N 15/85 (2013.01); C12P 21/00 (2013.01); C12N 2800/107 (2013.01); C12N 2800/24 (2013.01);
Abstract

The present invention provides a method of maintaining a gram negative bacterium plasmid without the use of antibiotic selection pressure. Further, the invention relates to the drugless plasmids produced including drugless plasmids containing a heterologous gene. The invention also provides formulations and/or compositions comprising the drugless plasmids comprising a heterologous gene, formulations and/or compositions comprising a protein or an immunogen expressed using the drugless plasmids, and methods of administering such formulations and/or compositions to a host. The invention relates to gram negative bacteria containing the drugless plasmids.


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