The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 26, 2019

Filed:

Apr. 01, 2016
Applicants:

Nantbio, Inc., Culver City, CA (US);

Nantomics, Llc, Culver City, CA (US);

Nant Holdings Ip, Llc, Culver City, CA (US);

Inventors:

Shahrooz Rabizadeh, Agoura Hills, CA (US);

Kayvan Niazi, Encino, CA (US);

Oleksandr V. Buzko, Oak Park, CA (US);

Paul Weingarten, Anaheim, CA (US);

Heather McFarlane, Los Angeles, CA (US);

Anna Juncker-Jensen, Irvine, CA (US);

Justin Golovato, Los Angeles, CA (US);

Patrick Soon-Shiong, Culver City, CA (US);

Chunlin Tao, Newport Coast, CA (US);

David Ho, Los Angeles, CA (US);

Assignees:

NantBio, Inc., Culver City, CA (US);

NantOmics, LLC, Culver City, CA (US);

Nant Holdings IP, LLC, Culver City, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 417/12 (2006.01); C07D 417/14 (2006.01); A61K 31/427 (2006.01); C07D 417/04 (2006.01); C07D 277/46 (2006.01); C07D 471/06 (2006.01); C07F 9/6558 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 417/14 (2013.01); A61K 31/427 (2013.01); A61P 35/00 (2018.01); C07D 277/46 (2013.01); C07D 417/04 (2013.01); C07D 417/12 (2013.01); C07D 471/06 (2013.01); C07F 9/65583 (2013.01);
Abstract

Compounds and compositions are presented that inhibit K-ras, and especially mutant K-ras. Certain compounds preferentially or even selectively inhibit specific forms of mutant K-Ras, and particularly the G12D mutant form.


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