The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 26, 2019

Filed:

Sep. 21, 2018
Applicants:

Memorial Sloan Kettering Cancer Center, New York, NY (US);

Cornell University, Ithaca, NY (US);

Inventors:

Michelle S. Bradbury, New York, NY (US);

Barney Yoo, New York, NY (US);

Ulrich Wiesner, Ithaca, NY (US);

Kai Ma, Ithaca, NY (US);

Assignees:

Memorial Sloan Kettering Cancer Center, New York, NY (US);

Cornell University, Ithaca, NY (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61K 47/69 (2017.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 47/65 (2017.01); A61K 47/60 (2017.01); A61K 49/00 (2006.01); A61K 51/12 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6923 (2017.08); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 47/60 (2017.08); A61K 47/65 (2017.08); A61K 49/0093 (2013.01); A61K 51/1244 (2013.01);
Abstract

Described herein are nanoparticle drug conjugates (NDCs), which, in certain embodiments, comprise a non-toxic, multi-modality, clinically proven silica-based nanoparticle platform with covalently attached drug molecules/moieties. The nanoparticle drug conjugates (NDCs) demonstrate imaging capability and targeting ligands which efficiently clear through the kidneys. Furthermore, the conjugates incorporate therapeutic agents for cancer detection, prevention, and/or treatment.


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