The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 26, 2019

Filed:

Jun. 18, 2018
Applicants:

The United States of America, As Represented BY the Secretary, Department of Health & Human Services, Rockville, MD (US);

Sirnax, Inc., Ann Arbor, MI (US);

Inventors:

Bira Arya, Elliott City, MD (US);

Michael R. Simon, Ann Arbor, MI (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 47/64 (2017.01); C07K 14/52 (2006.01); C07K 14/005 (2006.01); A61K 31/713 (2006.01); C12N 15/87 (2006.01);
U.S. Cl.
CPC ...
A61K 47/64 (2017.08); A61K 31/713 (2013.01); A61K 47/642 (2017.08); A61K 47/6455 (2017.08); C07K 14/005 (2013.01); C07K 14/523 (2013.01); C12N 15/87 (2013.01); C07K 2319/10 (2013.01); C07K 2319/33 (2013.01); C07K 2319/74 (2013.01); C07K 2319/85 (2013.01);
Abstract

A fusion molecule is provided that includes one or more inhibitory nucleic acids, a targeting polypeptide, and a nucleic acid binding moiety. The targeting polypeptide and the nucleic acid binding moiety include specific the amino acid sequences. A fusion molecule is also provided that includes one or more inhibitory nucleic acids, a targeting polypeptide, and a nucleic acid binding moiety adapted to bind a double-stranded RNA or to a small hairpin RNA. The targeting polypeptide being CCL27 or CCL11 or a fragment thereof.


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