The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 26, 2019

Filed:

Mar. 14, 2014
Applicants:

President and Fellows of Harvard College, Cambridge, MA (US);

Massachusetts Institute of Technology, Cambridge, MA (US);

The Brigham and Women's Hospital, Inc., Boston, MA (US);

Inventors:

Georg Stary, Brookline, MA (US);

Aleksandar Filip Radovic-Moreno, State College, PA (US);

Pamela A. Basto, Cambridge, MA (US);

Michael N. Starnbach, Needham, MA (US);

Robert S. Langer, Newton, MA (US);

Omid C. Farokhzad, Waban, MA (US);

Ulrich Von Andrian, Chestnut Hill, MA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/118 (2006.01); A61K 45/06 (2006.01); A61K 31/4745 (2006.01); A61K 31/711 (2006.01); A61K 39/02 (2006.01); A61K 39/04 (2006.01); A61K 39/085 (2006.01); A61K 39/09 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/118 (2013.01); A61K 31/4745 (2013.01); A61K 31/711 (2013.01); A61K 39/0208 (2013.01); A61K 39/04 (2013.01); A61K 39/085 (2013.01); A61K 39/092 (2013.01); A61K 45/06 (2013.01); A61K 2039/521 (2013.01); A61K 2039/5252 (2013.01); A61K 2039/543 (2013.01); A61K 2039/55555 (2013.01); A61K 2039/55572 (2013.01); C12N 2740/16034 (2013.01); C12N 2760/16134 (2013.01); C12N 2760/18534 (2013.01); C12N 2770/16034 (2013.01); C12N 2770/20034 (2013.01); Y02A 50/386 (2018.01); Y02A 50/388 (2018.01); Y02A 50/403 (2018.01); Y02A 50/466 (2018.01); Y02A 50/478 (2018.01); Y02A 50/48 (2018.01); Y02A 50/484 (2018.01);
Abstract

Provided herein are new compositions including an inactivated pathogen and one or more adjuvant-loaded polymeric nanoparticles, wherein the adjuvant-loaded nanoparticles are bound to the inactivated pathogen. These compositions are useful for preventing and/or treating diseases caused by the specific pathogens, especially when administered to a subject's mucosal membranes.


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