The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 26, 2019
Filed:
Jun. 05, 2015
Glaxosmithkline Intellectual Property (No. 2) Limited, Brentford, Middlesex, GB;
Bruce G. Szczepankiewicz, Hopkinton, MA (US);
Frank Preugschat, Research Triangle Park, NC (US);
Karsten Koppetsch, Woburn, MA (US);
Robert B. Perni, Marlborough, MA (US);
GlaxoSmithKline Intellectual Property (No. 2) Limited, Brentford, Middlesex, GB;
Abstract
Provided herein are stereoisomerically pure ester and carbonate analogues of nicotinamide riboside and nicotinamide riboside hydride, and pharmaceutical compositions and uses thereof. The stereoisomerically pure ester and carbonate analogues of nicotinamide riboside and nicotinamide riboside hydride may be used to treat a disease or disorder that would benefit from increased NAD levels including a mitochondrial disease or disorder, insulin resistance, a metabolic syndrome, diabetes, obesity, for increasing insulin sensitivity in a subject, or to treat or prevent a skin condition. The compounds have general formulas (I) or (II): wherein Ris —C(═O)—X—(C-Cstraight chain or branched) alkyl or —C(═O)—X—(C-Cstraight chain or branched) alkenyl; each Ris independently selected from hydrogen, and a —C(O)—X—(C-Cstraight chain or branched) alkyl or a —C(O)—X—(C-Cstraight chain or branched) alkenyl; and X is a covalent bond or O.