The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 26, 2019

Filed:

Nov. 15, 2016
Applicant:

Cornell Research Foundation, Inc., Ithaca, NY (US);

Inventors:

Steven A. Goldman, Webster, NY (US);

Fraser Sim, Batavia, NY (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); A61P 25/28 (2006.01); A61K 31/555 (2006.01); A61K 31/737 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
A61K 31/555 (2013.01); A61K 31/737 (2013.01); G01N 33/6896 (2013.01); G01N 2500/00 (2013.01); G01N 2800/28 (2013.01);
Abstract

The present invention relates to a method of modulating production of neurons and/or oligodendrocytes from neural progenitor cells of human white matter and to a method of treating a subject for a condition modulated by underproduction of oligodendrocytes from human white matter. Both of these methods involve administering an agonist or antagonist of one or more molecules set forth in Tables 1 and/or 2 to the neural progenitor cells. Also disclosed is a method of using an inhibitor of sterol synthesis to differentiate oligodendrocyte progenitor cells to oligodendrocytes.


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