The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 26, 2019
Filed:
Aug. 25, 2015
Applicant:
University of Canberra, Bruce, AU;
Inventors:
Sudha Rao, McKellar, AU;
Anjum Zafar, Bruce, AU;
Assignee:
EpiAxis Therapeutics Pty Ltd., Canberra, AU;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07H 21/04 (2006.01); A61K 31/166 (2006.01); A61K 45/06 (2006.01); A61K 31/137 (2006.01); A61K 31/337 (2006.01); A61K 31/496 (2006.01); A61K 31/713 (2006.01); C12N 15/113 (2010.01); C12Q 1/6886 (2018.01); G01N 33/574 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/166 (2013.01); A61K 31/137 (2013.01); A61K 31/337 (2013.01); A61K 31/496 (2013.01); A61K 31/713 (2013.01); A61K 45/06 (2013.01); C12N 15/1137 (2013.01); C12Q 1/6886 (2013.01); C12Y 114/11 (2013.01); G01N 33/574 (2013.01); G01N 33/57415 (2013.01); G01N 33/57492 (2013.01); G01N 33/57496 (2013.01); A61K 38/00 (2013.01); C12N 2310/14 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/47 (2013.01); G01N 2333/70585 (2013.01); G01N 2333/70596 (2013.01); G01N 2333/912 (2013.01);
Abstract
Disclosed are compositions and methods for modulating cancer stem cells. More particularly, the present invention discloses the use of lysine demethylase (LSD) inhibitors and protein kinase C theta inhibitors (PKC-θ) for inhibiting the growth of LSD- and/or PKC-θ-overexpressing cells including cancer stem cells, for enhancing the biological effects of chemotherapeutic drugs or irradiation on cancer cells, for treating cancer, including non-metastatic and metastatic cancer and/or for preventing cancer recurrence.