The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2019
Filed:
Jun. 01, 2016
Applicant:
California Institute of Technology, Pasadena, CA (US);
Inventors:
James R. Heath, South Pasadena, CA (US);
Songming Peng, Pasadena, CA (US);
Assignee:
California Institute of Technology, Pasadena, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/53 (2006.01); C12Q 1/68 (2018.01); C07H 21/04 (2006.01); G01N 33/569 (2006.01); C12Q 1/6804 (2018.01); G01N 15/14 (2006.01); G01N 33/574 (2006.01); G01N 33/68 (2006.01); G01N 15/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/56972 (2013.01); C07H 21/04 (2013.01); C12Q 1/6804 (2013.01); G01N 15/14 (2013.01); G01N 33/574 (2013.01); G01N 33/6878 (2013.01); G01N 2015/008 (2013.01); G01N 2015/149 (2013.01); G01N 2333/70539 (2013.01); G01N 2458/10 (2013.01);
Abstract
Compositions and methods for isolating patient-derived antigen-specific T cells include an antigen complex having a polynucleotide barcoded nanoparticle sorting agent complexed with a peptide-loaded streptavidin major histocompatability complex (MHC) tetramer, the barcoding technology allowing for high fidelity screening of a library of the antigen complexes to readily isolate and identify antigen-specific T cells.