The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2019
Filed:
Apr. 09, 2014
Base4 Innovation Ltd, Cambridge, Cambridgeshire, GB;
Medical Research Council, Swindon, Wiltshire, GB;
Cameron Alexander Frayling, Cambridgeshire, GB;
Barnaby Balmforth, Cambridgeshire, GB;
Bruno Flavio Nogueira de Sousa Soares, Cambridgeshire, GB;
Thomas Henry Isaac, Cambridgeshire, GB;
Boris Breiner, Cambridgeshire, GB;
Alessandra Natale, Cambridgeshire, GB;
Michele Amasio, Cambridgeshire, GB;
Paul Dear, Wiltshire, GB;
BASE4 INNOVATION LTD, Cambridge, Cambridgeshire, GB;
UNITED KINGDOM RESEARCH AND INNOVATION, Swindon, GB;
Abstract
A method for determining the sequence of nucleotide bases in a polynucleotide analyte is provided. It is characterised by the steps of (1) generating a stream of single nucleotide bases from the analyte; (2) producing captured molecules by reacting each single nucleotide base with a capture system; (3) amplifying at least part of the captured molecule to produce a plurality of amplicons characteristic of the single nucleotide base; (4) labelling the amplicons with a corresponding probe having a characteristic detectable element and (5) detecting a property characteristic of the detectable element.