The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2019
Filed:
Oct. 16, 2018
Applicant:
Blue Sky Vaccines Gmbh, Vienna, AT;
Inventors:
Thomas Muster, Vienna, AT;
Markus Wolschek, Vienna, AT;
Assignee:
BLUE SKY VACCINES GMBH, Vienna, AT;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); C07K 14/005 (2006.01); C12N 7/00 (2006.01); A61K 35/768 (2015.01); A61K 38/19 (2006.01); A61K 39/395 (2006.01); C07K 14/535 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 35/768 (2013.01); A61K 38/193 (2013.01); A61K 39/395 (2013.01); C07K 14/005 (2013.01); C07K 14/535 (2013.01); C12N 7/00 (2013.01); A61K 2039/505 (2013.01); C12N 2760/16122 (2013.01); C12N 2760/16132 (2013.01); C12N 2760/16143 (2013.01); C12N 2760/16145 (2013.01); C12N 2760/16151 (2013.01); C12N 2760/16162 (2013.01);
Abstract
The present invention provides a recombinant influenza virus vector comprising an NS gene encoding a truncated NS1 protein of at least 73 and up to 122 amino acids of the N-terminus of the respective wild type NS1 protein, wherein the vector replicates in IFN-sensitive tumor cells and does not replicate in normal, non-tumor cells, and expresses a heterologous immunostimulatory polypetide. The invention further provides a pharmaceutical composition containing the influenza virus vector, its use for the treatment of cancer patients and methods for producing the influenza virus vaccine.