The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2019
Filed:
Dec. 18, 2018
Applicant:
Bethphagen Inc., Gwangju, KR;
Inventors:
Assignee:
BETHPHAGEN INC., Gwangju, KR;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 7/06 (2006.01); C07K 14/00 (2006.01); C07K 14/47 (2006.01); A61K 38/00 (2006.01); C07K 7/00 (2006.01); A61K 38/08 (2019.01);
U.S. Cl.
CPC ...
C07K 7/06 (2013.01); A61K 38/005 (2013.01); A61K 38/08 (2013.01); C07K 7/00 (2013.01); C07K 14/00 (2013.01); C07K 14/47 (2013.01); C07K 14/4703 (2013.01);
Abstract
The present invention relates to decoy peptide or polypeptide consisting of a peptide sequence represented by the following Formula I: X-Ala-X-X-Ile-Glu-X(I). It is noteworthy that the decoy peptide or polypeptide of the present invention significantly elevates phosphorylation levels of PLB by inhibiting PP1-mediated dephosphorylation. In addition, the decoy peptide or polypeptide provides cardio-protective effects by restoring of SERCA2a activity and inotropic effect of enhancing myocardial contractility. The present invention will contribute greatly to the prevention or treatment of diseases associated with PLB.