The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2019
Filed:
May. 19, 2017
Applicant:
Trustees of Tufts College, Medford, MA (US);
Inventors:
David L. Kaplan, Concord, MA (US);
Fiorenzo G. Omenetto, Lexington, MA (US);
Jeffrey K. Marchant, Littleton, MA (US);
Noorjahan Panjwani, Medford, MA (US);
Brian Lawrence, Minneapolis, MN (US);
Assignee:
TRUSTEES OF TUFTS COLLEGE, Medford, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A01N 1/02 (2006.01); A61L 27/36 (2006.01); A61L 27/22 (2006.01); A61L 27/38 (2006.01); A61L 27/56 (2006.01); C12N 5/00 (2006.01); C12N 5/079 (2010.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
A61L 27/3604 (2013.01); A61L 27/225 (2013.01); A61L 27/227 (2013.01); A61L 27/3804 (2013.01); A61L 27/3839 (2013.01); A61L 27/3891 (2013.01); A61L 27/56 (2013.01); C12N 5/0068 (2013.01); C12N 5/0621 (2013.01); G01N 33/5044 (2013.01); A61L 2300/412 (2013.01); C12N 2533/50 (2013.01);
Abstract
This invention relates to a lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells. The silk fibroin substrates provides an excellent means of controlling and culturing cell and extracellular matrix development. A multitude of lamellae tissue layers can be used to create a tissue-engineered organ, such as a tissue-engineered cornea. The tissue-engineered organ is non-immunogenic and biocompatible.