The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2019
Filed:
Dec. 15, 2016
Applicant:
University of Pittsburgh-of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Inventors:
Wei Qian, Pittsburgh, PA (US);
Peter Wipf, Pittsburgh, PA (US);
Bennett Van Houten, Pittsburgh, PA (US);
Assignee:
University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/517 (2006.01); A61K 31/513 (2006.01); A61K 31/428 (2006.01); A61K 31/44 (2006.01); A61K 31/282 (2006.01); A61K 31/4436 (2006.01); A61K 33/24 (2019.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/517 (2013.01); A61K 31/282 (2013.01); A61K 31/428 (2013.01); A61K 31/44 (2013.01); A61K 31/4436 (2013.01); A61K 31/513 (2013.01); A61K 33/24 (2013.01); A61K 45/06 (2013.01);
Abstract
The present invention relates to compositions and methods for reducing cell proliferation and/or promoting cell death. It is based, at least in part, on the discovery that in platinum drug-resistant cell lines, certain compounds, together with a second antiproliferative agent (e.g., cisplatin), act synergistically to promote apoptosis. Accordingly, the present invention provides for novel anticancer strategies.