The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 12, 2019

Filed:

Nov. 15, 2013
Applicant:

The Administrators of the Tulane Educational Fund, New Orleans, LA (US);

Inventors:

Suzanne L. Tomchuck, Memphis, TN (US);

Elizabeth B. Norton, New Orleans, LA (US);

Robert F. Garry, New Orleans, LA (US);

Bruce Bunnell, Mandeville, LA (US);

John D. Clements, New Orleans, LA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/85 (2006.01); A61K 39/12 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/85 (2013.01); A61K 39/12 (2013.01); A61K 2039/5156 (2013.01); C12N 2740/16134 (2013.01); Y02A 50/388 (2018.01); Y02A 50/39 (2018.01); Y02A 50/394 (2018.01); Y02A 50/396 (2018.01); Y02A 50/403 (2018.01); Y02A 50/407 (2018.01); Y02A 50/41 (2018.01); Y02A 50/412 (2018.01); Y02A 50/421 (2018.01); Y02A 50/423 (2018.01); Y02A 50/466 (2018.01); Y02A 50/469 (2018.01); Y02A 50/478 (2018.01); Y02A 50/484 (2018.01); Y02A 50/487 (2018.01); Y02A 50/491 (2018.01);
Abstract

Episomally transfected primary mesenchymal stem cells (MSC) express a polypeptide consisting of an antigenic polypeptide (e.g., one or more polypeptides) relating to a pathogen (e.g., one or more virus, bacterium, or parasite). The antigenic polypeptide can have the amino acid sequence of a natural polypeptide from the pathogen or an amino acid sequence differing from the natural sequence by one or more conservative amino acid substitutions. Uses and method for treating or preventing infections with episomally transfected primary MSC also are described.


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