The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 2019
Filed:
Mar. 25, 2011
Sam Philip Heywood, Berkshire, GB;
David Paul Humphreys, Berkshire, GB;
Sam Philip Heywood, Berkshire, GB;
David Paul Humphreys, Berkshire, GB;
UCB BIOPHARMA SPRL, Brussels, BE;
Abstract
The present disclosure provides a binding protein comprising: a polypeptide heavy chain comprising: VH-(X)n-VH—CH (X)y wherein VHis a first variable domain, VHis a second variable domain, CH is a constant domain, Xrepresents an amino acid or peptide, Xrepresents an Fc region, n is 0 or 1 and y is independently 1 or 2, and a polypeptide light chain comprising: VL-(X)n-VL-C wherein VL1 is a first variable domain, VLis a second variable domain, C is a constant domain, Xrepresents an amino acid or peptide and n is 0 or 1, wherein the heavy chain and light chain are aligned such that VHand VLform a first binding domain, and VHand VLform a second binding domain and wherein: there is a disulfide bond between VHand VL, and/or there is a disulfide bond between VHand VL, and use thereof in treatment.