The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 12, 2019

Filed:

Mar. 02, 2016
Applicant:

Amgen Inc., Thousand Oaks, CA (US);

Inventors:

Matthew Weiss, Boston, MA (US);

Benjamin Charles Milgram, Cambridge, MA (US);

Thomas Dineen, Somerville, MA (US);

John Stellwagen, Beverly, MA (US);

Angel Guzman-Perez, Belmont, MA (US);

Alessandro Boezio, Somerville, MA (US);

Issac E. Marx, Arlington, MA (US);

Assignee:

AMGEN INC., Thousand Oaks, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4375 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01);
Abstract

The present invention provides compounds of Formula (I), wherein: as defined in the specification, an enantiomer, diastereomer, atropisomer thereof, or a mixture thereof, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders, cough, or itch. Also provided are pharmaceutical compositions containing compounds of the present invention.


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