The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 2019
Filed:
Jan. 30, 2017
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Merck Sharp & Dohme Limited, Hoddesdon, Hertfordshire, GB;
Aaron M. Dumas, Hertford, GB;
Jeremy P. Scott, Hertford, GB;
Michael Shevlin, Middlesex, NJ (US);
Zhijian Liu, Kendall Park, NJ (US);
John Y. L. Chung, Edison, NJ (US);
Feng Xu, Staten Island, NY (US);
Dongfang Meng, Morganville, NJ (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Merck Sharp & Dohme Limited, Hoddesdon, Hertfordshire, GB;
Abstract
The present invention relates to processes for the preparation of N-protected 4-((2S,5R)-5-((benzyloxy)amino)piperidine-2-carboxamido)piperidine-1-carboxylates. Such compounds have application in the preparation of beta-lactamase inhibitors such as 7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamides and esters, in particular, the beta lactamase inhibitor, (2S,5R)-7-oxo-N-piperidin-4-yl-6-(sulfoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide. The present invention also encompasses intermediates useful in the disclosed processes and methods for their preparation.