The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 12, 2019

Filed:

Feb. 29, 2016
Applicants:

Apeiron Biologics Ag, Vienna, AT;

Evotec Ag, Hamburg, DE;

Inventors:

Monika Ermann, Oxfordshire, GB;

Guenther Lametschwandtner, Vienna, AT;

Patricia Leonie Amouzegh, Oxfordshire, GB;

Russell Stuart Craft, Groningen, NL;

Thomas Hanke, Hamburg, DE;

Timothy Robin James, Oxfordshire, GB;

Severine Danielle Jones, Oxfordshire, GB;

Hans Loibner, Vienna, AT;

Pui Leng Loke, Oxfordshire, GB;

Ina Sternberger, Hamburg, DE;

Anton Stuetz, Altmuenster, AT;

Roland Wehr, Goettingen, DE;

Mark Whittaker, Oxfordshire, GB;

Assignees:

APEIRON BIOLOGICS AG, Vienna, AT;

EVOTEC SE, Hamburg, DE;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 285/36 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); A61P 35/00 (2006.01); A61K 31/554 (2006.01); A61K 45/06 (2006.01); C07D 417/06 (2006.01); C07D 417/10 (2006.01); C07D 513/04 (2006.01); C12N 5/0781 (2010.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
C07D 285/36 (2013.01); A61K 31/554 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07D 417/06 (2013.01); C07D 417/10 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 513/04 (2013.01); C12N 5/0635 (2013.01); C12N 5/0636 (2013.01); C12N 5/0646 (2013.01); C12N 2501/2302 (2013.01); C12N 2501/999 (2013.01);
Abstract

The present invention relates to bicyclic tetrahydrothiazepine of formula (I), wherein Rto R, X, Xand Rhave the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising such compounds as well as their use as medicaments, especially in methods for the treatment or prevention of a neoplastic and/or infectious disease and in vitro methods.


Find Patent Forward Citations

Loading…