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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10472328 B1

PDFFull Text
Date of Patent:
Nov. 12, 2019

Filed:

Dec. 19, 2018

Pkm2 modulators and methods for their use

Applicant:

Tolero Pharmaceuticals, Inc., Lehi, UT (US);

Inventors:

Koc-Kan Ho, Holladay, UT (US);

Yong Xu, Midvale, UT (US);

Michael David Saunders, Sandy, UT (US);

Xiaohui Liu, Holladay, UT (US);

Scott Albert Pearce, Clearfield, UT (US);

Kevin Bret Wright, Cottonwood Heights, UT (US);

Jason Marc Foulks, Draper, UT (US);

Kenneth Mark Parnell, Kaysville, UT (US);

Steven Brian Kanner, Salt Lake City, UT (US);

David Lee Vollmer, South Jordan, UT (US);

Jihua Liu, San Marcos, CA (US);

Assignee:

TOLERO PHARMACEUTICALS, INC., Lehi, UT (US);

Attorney:

Seed Intellectual Property Law Group LLP

Primary Examiner:

Amanda L Aguirre

Int. Cl.
CPC ...
C07D 409/12 (2006.01); C07D 409/14 (2006.01); A61K 31/415 (2006.01); C07D 231/14 (2006.01); C07D 231/38 (2006.01); C07F 9/6503 (2006.01); C07D 403/12 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 231/16 (2006.01); C07D 401/12 (2006.01); C07D 403/14 (2006.01); C07D 405/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01);
U.S. Cl.
CPC ...
C07D 231/14 (2013.01); C07D 231/16 (2013.01); C07D 231/38 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07F 9/65031 (2013.01);
Abstract

Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R, R, R, R, Rand Rare as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

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