The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 2019
Filed:
Sep. 12, 2014
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventors:
Galen Loving, Berkeley, CA (US);
Peter D. Caravan, Cambridge, MA (US);
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 51/00 (2006.01); A61M 36/14 (2006.01); A61K 51/08 (2006.01); A61K 49/00 (2006.01); A61K 49/14 (2006.01); C07K 7/08 (2006.01);
U.S. Cl.
CPC ...
A61K 51/088 (2013.01); A61K 49/0056 (2013.01); A61K 49/14 (2013.01); A61K 51/08 (2013.01); C07K 7/08 (2013.01);
Abstract
Provided herein are methods for determining the presence or absence of active thrombus formation using a linear polypeptide that binds fibrin upon cyclization. Also provided are compounds comprising linear polypeptide probes that are cyclized in the presence of protein disulfide isomerase.