The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 2019
Filed:
Feb. 06, 2018
Applicant:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Inventors:
Seoju Lee, Madison, AL (US);
David C. Wylie, Cranford, NJ (US);
Susan V. Cannon-Carlson, Wayne, NJ (US);
Assignee:
Merck Sharp & Dohme Ltd, Rahwasy, NJ (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/20 (2006.01); C07K 14/54 (2006.01); A61K 47/60 (2017.01);
U.S. Cl.
CPC ...
A61K 38/2066 (2013.01); A61K 47/60 (2017.08); C07K 14/5428 (2013.01); C07K 2319/31 (2013.01);
Abstract
Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10.