The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 12, 2019

Filed:

Mar. 25, 2016
Applicant:

Temple University—of the Commonwealth System of Higher Education, Philadelphia, PA (US);

Inventors:

Salim Merali, Bryn Mawr, PA (US);

Steven G. Kelsen, Rydal, PA (US);

Carlos A. Barrero, Philadelphia, PA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/53 (2006.01); A61K 31/7072 (2006.01); G01N 33/68 (2006.01); A61K 31/365 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7072 (2013.01); A61K 31/365 (2013.01); G01N 33/6893 (2013.01); G01N 2800/122 (2013.01); G01N 2800/50 (2013.01); G01N 2800/56 (2013.01); G01N 2800/60 (2013.01);
Abstract

The methods described herein are based on the discovery that the plasma level of a panel of specific proteins differs between two subject populations: 1) subjects at risk for chronic obstructive pulmonary disease ('COPD') but not manifesting clinical symptoms of COPD; and 2) subjects having very severe COPD. The difference in plasma levels is statistically significant for each protein. The identification of these proteins thus facilitates susceptibility detection, early disease detection, disease severity assessment, disease progression monitoring, and therapy efficacy monitoring.


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