The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 05, 2019
Filed:
Jun. 06, 2014
Applicant:
Nanyang Technological University, Singapore, SG;
Inventors:
Assignee:
Nanyang Technological University, Singapore, SG;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 21/65 (2006.01); H01L 27/28 (2006.01); H01L 51/00 (2006.01); B82Y 15/00 (2011.01); G01N 33/20 (2019.01); G01N 33/02 (2006.01); G01N 33/483 (2006.01);
U.S. Cl.
CPC ...
G01N 21/658 (2013.01); B82Y 15/00 (2013.01); G01N 33/20 (2013.01); H01L 27/28 (2013.01); H01L 51/0093 (2013.01); G01N 33/02 (2013.01); G01N 33/483 (2013.01);
Abstract
The present invention relates to a logic gate, comprising a metamaterial surface enhanced Raman scattering (MetaSERS) sensor, comprising (a) alphabetical metamaterials in the form of split ring resonators operating in the wavelength range of from 560 to 2200 nm; and (b) a guanine (G) and thymine (T)-rich oligonucleotide that can, upon presence of potassium cations (K), fold into a G-quadruplex structure, and in presence of Hg, form a T-Hg-T hairpin complex that inhibits or disrupts the G-quadruplex structure formed in presence of K, as well as methods of operating and using such a logic gate.