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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10465194 B1

PDFFull Text
Date of Patent:
Nov. 05, 2019

Filed:

Jun. 08, 2016

Complement component irna compositions and methods of use thereof

Applicant:

Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);

Inventors:

Anna Borodovsky, Melrose, MA (US);

Brian Bettencourt, Groton, MA (US);

Assignee:

Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);

Attorneys:

McCarter & English, LLP

Maria Laccotripe Zacharakis

Deborah L. Nagle

Primary Examiner:

Dana H Shin

Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12N 15/113 (2010.01); A61K 38/12 (2006.01); A61K 31/713 (2006.01); A61K 39/395 (2006.01); C07K 16/18 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1137 (2013.01); A61K 31/713 (2013.01); A61K 38/12 (2013.01); A61K 39/3955 (2013.01); C07K 16/18 (2013.01); C12N 15/111 (2013.01); C12N 15/1138 (2013.01); C12N 2310/14 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2310/343 (2013.01); C12N 2310/346 (2013.01); C12N 2310/351 (2013.01); C12N 2320/51 (2013.01); C12Y 304/21047 (2013.01); Y02A 50/473 (2018.01);
Abstract

The invention relates to iRNA, e.g., double-stranded ribonucleic acid (dsRNA), compositions targeting the complement factor B (CFB) gene, the complement component C3 gene, and the complement component C9 gene and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of CFB, C9 and/or C3 and to treat subjects having a complement component-associated disease, e.g., paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome.

Find Patent Forward Citations

Borodovsky, Anna. (2019). Complement component irna compositions and methods of use thereof (U.S. Patent No. 10465194). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10465194

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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