The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 05, 2019
Filed:
Dec. 09, 2014
Applicants:
Nanyang Technological University, Singapore, SG;
Singapore Health Services Pte Ltd, Singapore, SG;
Inventors:
Subramanian Venkatraman, Singapore, SG;
Tzee Ling Tina Wong, Singapore, SG;
Bjorn Neu, Singapore, SG;
Assignees:
NANYANG TECHNOLOGICAL UNIVERSITY, Singapore, SG;
SINGAPORE HEALTH SERVICES PTE LTD, Singapore, SG;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 31/713 (2006.01); A61K 48/00 (2006.01); C12N 15/11 (2006.01); A61K 9/50 (2006.01); A61K 9/51 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 9/501 (2013.01); A61K 9/5036 (2013.01); A61K 9/5052 (2013.01); A61K 9/5078 (2013.01); A61K 9/5089 (2013.01); A61K 31/713 (2013.01); A61K 48/0041 (2013.01); C12N 15/111 (2013.01); A61K 9/5107 (2013.01); C12N 2310/14 (2013.01); C12N 2320/32 (2013.01);
Abstract
The invention relates to a multilayered nanoparticle for delivery of RNA to a cell and methods of manufacturing and using the same. The multilayered nanoparticle has a core nanoparticle coated by alternating positively and negatively charged polymer layers, wherein the at least one of the negatively charged polymer layers is RNA.