The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 05, 2019
Filed:
May. 13, 2016
Applicant:
The Board of Regents of the University of Oklahoma, Norman, OK (US);
Inventor:
Augen A. Pioszak, Edmond, OK (US);
Assignee:
The Board of Regents of the University of Oklahoma, Norman, OK (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C07K 14/585 (2006.01); C07K 14/575 (2006.01);
U.S. Cl.
CPC ...
C07K 14/585 (2013.01); C07K 14/575 (2013.01); C07K 14/57527 (2013.01); A61K 38/00 (2013.01);
Abstract
Variant peptides of calcitonin gene-related peptide alpha (αCGRP), calcitonin gene-related peptide beta (βCGRP), and adrenomedullin (AM) are disclosed, wherein the variant peptides have high binding affinity and agonistic or antagonistic activity for at least one receptor complex of CLR:RAMP1, CLR:RAMP2, and CLR:RAMP3. Also disclosed are methods of use of the variant peptides in therapeutic treatments.