The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 05, 2019

Filed:

Dec. 18, 2015
Applicant:

Northwestern University, Evanston, IL (US);

Inventors:

Guillermo A. Ameer, Chicago, IL (US);

Jason A. Wertheim, Evanston, IL (US);

Bin Jiang, Evanston, IL (US);

Assignee:

Northwestern University, Evanston, IL (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61L 27/54 (2006.01); A61L 27/36 (2006.01); A61L 33/00 (2006.01); A61L 27/20 (2006.01); A61L 27/34 (2006.01); A61L 27/48 (2006.01); A61L 27/50 (2006.01); A61L 33/08 (2006.01); A61L 33/18 (2006.01); C08G 63/685 (2006.01); C08G 63/91 (2006.01);
U.S. Cl.
CPC ...
A61L 27/54 (2013.01); A61L 27/20 (2013.01); A61L 27/34 (2013.01); A61L 27/3633 (2013.01); A61L 27/48 (2013.01); A61L 27/507 (2013.01); A61L 33/0011 (2013.01); A61L 33/0088 (2013.01); A61L 33/08 (2013.01); A61L 33/18 (2013.01); C08G 63/6854 (2013.01); C08G 63/914 (2013.01); A61L 2300/236 (2013.01); A61L 2300/42 (2013.01);
Abstract

Provided herein are bioactivated polymer/extracellular matrix (ECM) composites and methods of preparation and use thereof. In particular, heparinized cysteine-polymer/ECM composites, and methods of preparation and use thereof, are provided. In some embodiments, provided herein are compositions comprising a composite of: (a) extracellular matrix (ECM), and (b) a polyester covalently linked to a bioactive agent. In some embodiments, the composite is a homogeneous composite. In some embodiments, the ECM is decellularized ECM. In some embodiments, the ECM is not substantially crosslinked.


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