The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 05, 2019
Filed:
Feb. 17, 2017
Applicant:
Lundbeck LA Jolla Research Center, Inc., San Diego, CA (US);
Inventors:
Cheryl A. Grice, Encinitas, CA (US);
Todd K. Jones, Solana Beach, CA (US);
Justin S. Cisar, San Diego, CA (US);
Iain Peter Fraser, Scotch Plains, NJ (US);
Assignee:
LUNDBECK LA JOLLA RESEARCH CENTER, INC., San Diego, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 51/00 (2006.01); A61M 36/14 (2006.01); A61K 51/04 (2006.01); C12N 9/20 (2006.01); A61B 6/03 (2006.01); C07B 59/00 (2006.01); C07D 295/205 (2006.01);
U.S. Cl.
CPC ...
A61K 51/0459 (2013.01); A61B 6/037 (2013.01); C07B 59/002 (2013.01); C07D 295/205 (2013.01); C12N 9/20 (2013.01); C12Y 301/01023 (2013.01); C07B 2200/05 (2013.01);
Abstract
Provided herein are monoacylglycerol lipase (MGLL) occupancy probes comprising a MGLL inhibitor containing a positron emission tomography (PET) tracer radionuclide. Also provided are methods of assessing MGLL enzyme occupancy of a MGLL inhibitor using the radiolabeled occupancy probes described herein.