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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10463742 B1

PDFFull Text
Date of Patent:
Nov. 05, 2019

Filed:

Apr. 17, 2019

Topical tetracycline compositions

Applicant:

Foamix Pharmaceuticals Ltd., Rehovot, IL;

Inventors:

Dov Tamarkin, Maccabim, IL;

Elana Gazal, Rehovot, IL;

Irakliy Papiashvili, Ashkelon, IL;

Yohan Hazot, Rehovot, IL;

David Schuz, Gimzu, IL;

Rita Keynan, Rehovot, IL;

Assignee:

Foamix Pharmaceuticals Ltd., Rehovot, IL;

Attorney:

Finnegan, Henderson, Farabow, Garrett & Dunner, LLP

Primary Examiner:

Jeffrey T Palenik

Int. Cl.
CPC ...
A61K 8/18 (2006.01); A61K 35/50 (2015.01); A61K 31/65 (2006.01); C07C 50/36 (2006.01); C07C 237/26 (2006.01); A61K 47/44 (2017.01); A61K 8/31 (2006.01); A61Q 17/04 (2006.01); A61K 9/12 (2006.01); A61K 31/4164 (2006.01); A61K 31/57 (2006.01); A61K 31/573 (2006.01); A61K 31/593 (2006.01); A61K 47/12 (2006.01); A61K 31/137 (2006.01); A61K 31/192 (2006.01); A61K 47/02 (2006.01); A61K 9/00 (2006.01); A61Q 19/00 (2006.01); A61Q 19/10 (2006.01); A61K 8/34 (2006.01); A61K 8/36 (2006.01); A61K 47/10 (2017.01); A61K 45/06 (2006.01); A61K 47/24 (2006.01); A61K 47/06 (2006.01);
U.S. Cl.
CPC ...
A61K 47/44 (2013.01); A61K 8/31 (2013.01); A61K 8/342 (2013.01); A61K 8/361 (2013.01); A61K 9/0014 (2013.01); A61K 9/0048 (2013.01); A61K 9/12 (2013.01); A61K 9/122 (2013.01); A61K 9/124 (2013.01); A61K 31/137 (2013.01); A61K 31/192 (2013.01); A61K 31/4164 (2013.01); A61K 31/57 (2013.01); A61K 31/573 (2013.01); A61K 31/593 (2013.01); A61K 31/65 (2013.01); A61K 45/06 (2013.01); A61K 47/02 (2013.01); A61K 47/06 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/24 (2013.01); A61Q 17/04 (2013.01); A61Q 19/00 (2013.01); A61Q 19/10 (2013.01); A61K 2800/31 (2013.01); A61K 2800/33 (2013.01);
Abstract

A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity or the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.

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