The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 05, 2019
Filed:
Oct. 14, 2016
Applicants:
Biomarin Pharmaceutical Inc., Novato, CA (US);
Ucl Business Plc, London, GB;
Inventors:
Peter Cameron Colosi, Novato, CA (US);
Amit Nathwani, London, GB;
Jenny McIntosh, London, GB;
Edward Tuddenham, London, GB;
Assignee:
BIOMARIN PHARMACEUTICAL INC., Novato, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 63/00 (2006.01); A61K 38/37 (2006.01); A61K 48/00 (2006.01); C12N 7/00 (2006.01); C07K 14/755 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
A61K 38/37 (2013.01); A61K 48/0058 (2013.01); A61K 48/0066 (2013.01); C07K 14/755 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); C12N 2750/14132 (2013.01); C12N 2750/14142 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14151 (2013.01); C12N 2800/22 (2013.01); C12N 2830/008 (2013.01);
Abstract
The invention provides improved adeno-associated virus (AAV) Factor VIII (FVIII) vectors, including AAV FVIII vectors that produce a functional Factor VIII polypeptide and AAV FVIII vectors with high expression activity.