The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 05, 2019

Filed:

Dec. 03, 2015
Applicants:

Tepha, Inc., Lexington, MA (US);

Evonik Corporation, Parsippany, NJ (US);

Inventors:

Peter Markland, Birmingham, AL (US);

Gary Anthony Winchester, Dora, AL (US);

Thomas Robert Tice, Indian Springs, AL (US);

David P. Martin, Arlington, MA (US);

Assignees:

TEPHA, INC., Lexington, MA (US);

EVONIK CORPORATION, Parsippany, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/16 (2006.01); A61K 9/00 (2006.01); A61K 9/50 (2006.01); A61L 27/34 (2006.01); A61L 31/10 (2006.01); A61K 31/485 (2006.01); A61K 38/09 (2006.01);
U.S. Cl.
CPC ...
A61K 9/1647 (2013.01); A61K 9/0019 (2013.01); A61K 9/5031 (2013.01); A61K 31/485 (2013.01); A61K 38/09 (2013.01); A61L 27/34 (2013.01); A61L 31/10 (2013.01); A61L 2400/06 (2013.01);
Abstract

Compositions and methods of making and using of microparticle compositions that provide faster flow or improved injectability through smaller or small-diameter needles have been developed. Notably, the microparticle compositions can be successfully delivered or administered through smaller-diameter needles than other microparticle compositions prepared from biocompatible or biodegradable polymers including, for example, poly(lactide), poly(lactide-co-glycolide), polycaprolactone, or poly-3-hydroxybutyrate. The microparticle compositions can exhibit a higher solids loading for a given needle size and/or faster flow through needles than other microparticle compositions. Further, blending or mixing the polymer of the microparticle composition with other polymer formulations can enhance the injectability of the resulting formulation.


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