The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 29, 2019

Filed:

Jul. 02, 2014
Applicant:

Universität Heidelberg, Heidelberg, DE;

Inventors:

Wilfried Roth, Schwetzingen, DE;

Georg Gdynia, Heidelberg, DE;

Sven Sauer, Mannheim, DE;

Assignee:

UNIVERSITÄT HEIDELBERG, Heidelberg, DE;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q 1/00 (2006.01); G01N 33/574 (2006.01); G01N 33/573 (2006.01);
U.S. Cl.
CPC ...
G01N 33/573 (2013.01); G01N 33/574 (2013.01); G01N 33/57484 (2013.01); C12Q 1/00 (2013.01); G01N 2333/90 (2013.01); G01N 2333/904 (2013.01); G01N 2333/90206 (2013.01); G01N 2333/90216 (2013.01); G01N 2333/91215 (2013.01); G01N 2800/50 (2013.01); G01N 2800/52 (2013.01); G01N 2800/54 (2013.01); G01N 2800/7028 (2013.01); G01N 2800/7066 (2013.01);
Abstract

A diagnostic method for the prediction of tumor prognosis including the likelihood of formation of metastases or of relapse or local recurrence in tumor related diseases in a mammal and the provision of a therapy recommendation for a patient the enzyme activity of key enzymes of the energy metabolism is determined in fresh tumor tissue or fresh tumor cell mass after 24 hours incubation in a cell culture medium. Incubation reduces nutrition, drug and biopsy/surgery effects on the energy metabolism of the tissue slices or the cell mass. The quotients of enzyme activity of anaerobic enzymes are put in ratio to the enzyme activity of aerobic enzymes or vice versa. Said ratio can be taken into account for prognosis of metastasis and a therapy recommendation.


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