The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 2019
Filed:
Nov. 20, 2015
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
David Frendewey, New York, NY (US);
Ka-Man Venus Lai, San Francisco, CA (US);
Wojtek Auerbach, Ridgewood, NJ (US);
Gustavo Droguett, New City, NY (US);
Anthony Gagliardi, Hopewell Junction, NY (US);
David M. Valenzuela, Yorktown Heights, NY (US);
Vera Voronina, Sleepy Hollow, NY (US);
Lynn Macdonald, Harrison, NY (US);
Andrew J. Murphy, Croton-on-Hudson, NY (US);
George D. Yancopoulos, Yorktown Heights, NY (US);
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Abstract
Compositions and methods are provided for creating and promoting biallelic targeted modifications to genomes within cells and for producing non-human animals comprising the modified genomes. Also provided are compositions and methods for modifying a genome within a cell that is heterozygous for an allele to become homozygous for that allele. The methods make use of Cas proteins and two or more guide RNAs that target different locations within the same genomic target locus. Also provided are methods of identifying cells with modified genomes.