The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 2019
Filed:
Dec. 22, 2015
Applicant:
Dublin City University, Dublin, IE;
Inventors:
Assignee:
Dublin City University, Dublin, IE;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/52 (2006.01); A61K 38/48 (2006.01); C07K 14/33 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/52 (2013.01); A61K 38/4893 (2013.01); C07K 14/33 (2013.01); C12Y 304/24069 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/50 (2013.01); Y02A 50/469 (2018.01);
Abstract
The invention includes Clostridial neurotoxin derivatives containing at least two light chain endopeptidase domains, and nucleic acids encoding such Clostridial neurotoxin derivatives. In preferred embodiments, the invention includes methods and compositions for the treatment of inflammatory disorders (such as arthritis); chronic pain, such as neuropathic pain and inflammatory pain through the use of such Clostridial neurotoxin derivatives, including those derived from an intact BoNT/A having an LC/E-derived endopeptidase joined to the LC/A endopeptidase.