The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 2019
Filed:
Sep. 08, 2017
International Business Machines Corporation, Armonk, NY (US);
Agency for Science, Technology and Research (Astar), Singapore, SG;
Dylan J. Boday, Tucson, AZ (US);
Willy Chin, Singapore, SG;
Jeannette M. Garcia, San Leandro, CA (US);
James L. Hedrick, Pleasanton, CA (US);
Eunice Leong Jiayu, Singapore, SG;
Shrinivas Venkataraman, Singapore, SG;
Zhi Xiang Voo, Singapore, SG;
Rudy J. Wojtecki, San Jose, CA (US);
Yi Yan Yang, Singapore, SG;
International Business Machines Corporation, Armonk, NY (US);
Abstract
The present disclosure relates to polythioaminals with applications as carriers or delivery vehicles for therapeutic agents or other small molecule cargo. Polythioaminal block copolymer coupled to a therapeutic agent is a polymer-therapeutic conjugate that exhibits higher stability and longer life time in aqueous environments. The polythioaminal block copolymer coupled to a therapeutic agent can be synthesized by reacting hexahydrotriazines with a hydrophobic block precursor, a hydrophilic block precursor, a particle stabilizing segment precursor, and a cargo, such as a therapeutic agent, in a one pot synthesis. The ease of synthesizing the resulting polythioaminal block copolymer coupled to the therapeutic agent while offering the extended stability and polymer life time in aqueous environments make the polythioaminal block copolymer particularly attractive for therapeutic carriers.