The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 29, 2019

Filed:

Jul. 20, 2017
Applicants:

International Business Machines Corporation, Armonk, NY (US);

Nanomalaysia Berhad, Kuala Lumpur, MY;

Inventors:

Mohd Zulkefeli Bin Mat Jusoh, Kuala Lumpur, MY;

Alshakim Nelson, Montlake, WA (US);

Victoria A. Piunova, Los Gatos, CA (US);

Joseph Sly;

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C08F 212/08 (2006.01); C08F 212/36 (2006.01); A61K 9/00 (2006.01); A61K 47/32 (2006.01); A61K 47/34 (2017.01); A61K 9/107 (2006.01); A61K 47/42 (2017.01); C08F 297/02 (2006.01); C08F 295/00 (2006.01); A61K 9/20 (2006.01);
U.S. Cl.
CPC ...
C08F 212/08 (2013.01); A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 9/1075 (2013.01); A61K 47/32 (2013.01); A61K 47/34 (2013.01); A61K 47/42 (2013.01); C08F 212/36 (2013.01); C08F 295/00 (2013.01); C08F 297/02 (2013.01); A61K 9/0031 (2013.01); A61K 9/0095 (2013.01); A61K 9/2063 (2013.01); C08F 2438/01 (2013.01); C08F 2500/24 (2013.01);
Abstract

Star polymer occlusion complexes were prepared comprising i) an amphiphilic unimolecular star polymer having a crosslinked core covalently linked to 6 or more independent amphiphilic polymer arms, ii) a nutraceutical (such as coenzyme Q10), and iii) a cholesterol-lowering drug (such as simvastatin). An initial occlusion complex formed with the nutraceutical and the star polymer exhibited improved binding properties for the cholesterol-lowering drug, resulting in improved loading efficiencies for the cholesterol-lowering drug. The star polymer occlusion complexes have utility in the medical treatment of high blood cholesterol.


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