The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 2019
Filed:
Jul. 18, 2016
Applicants:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Fondazione Irccs Istituto Nazionale Dei Tumori, Milan, IT;
Inventors:
Daniel J. Powell, Bala Cynwyd, PA (US);
George Coukos, Wynnewood, PA (US);
Mariangela Figini, Milan, IT;
Silvana Canevari, Milan, IT;
Assignees:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, IT;
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 35/17 (2015.01); C07K 14/705 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); C07K 14/725 (2006.01); A61K 35/12 (2015.01);
U.S. Cl.
CPC ...
C07K 16/28 (2013.01); A61K 35/17 (2013.01); A61K 39/0011 (2013.01); A61K 39/39558 (2013.01); C07K 14/705 (2013.01); C07K 14/7051 (2013.01); C07K 14/70517 (2013.01); C07K 14/70578 (2013.01); A61K 2035/124 (2013.01); A61K 2039/505 (2013.01); A61K 2039/5156 (2013.01); A61K 2039/5158 (2013.01); C07K 2317/622 (2013.01); C07K 2318/20 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01); C07K 2319/74 (2013.01);
Abstract
The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell having α-folate receptor (FRα) binding domain and 4-1BB (CD137) costimulatory domain to treat ovarian cancer.